Letter: Enzymatic estimate of infarct size.
نویسندگان
چکیده
منابع مشابه
An improved basis for enzymatic estimation of infarct size.
Infarct size has been estimated from serial serum creatine phosphokinase (CPK) changes, but the contribution of noncardiac CPK may interfere. Results would also be influenced if CPK disappearance varied with hemodynamic changes. Since MB CPK is a marker more specific to myocardium. infarct size was estimated from serum MB changes in 16 patients. In addition, 21 chronically instrumented consciou...
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The possibility of predicting myocardial infarct size from early enzyme measurements was studied using a physiological two compartment distribution model. Based on this the time dependent appearance function in plasma was calculated for creatine kinase, aspartate aminotransferase, and lactate dehydrogenase in 29 patients suffering from acute myocardial infarction. On average, the appearance fun...
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T he causal relationship between the rise in activity of certain enzymes in the serum and the occurrence of damage to the myocardium has been established without question. Experiments and histochemical investigations have shown that infarcted heart muscle is rapidly depleted of various enzymes, and that these enzymes appear in an active form in the blood that drains from the infarcted myocardiu...
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To the Editor: The article by Maroko and his co-workers entitled "Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions" (Circulation 43:67, 1971) is indeed a very interesting one and an enthusiastic approach to the problem of modification of the size of an infarct. However, there are several points with regard to the methods that seem to need some clarification. Th...
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Enzymatic estimates of myocardial infarct size based on plasma levels of MB creatine kinase (MB-CK) were compared with anatomic infarct size in 49 human hearts obtained at autopsy. The patients studied had been enrolled in the Multicenter Investigation of Limitation of Infarct Size (MILIS) study program within 18 hr of the onset of acute infarction and were treated at one of five participating ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1976
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.54.1.1277419